Search results for " Humulus lupulus"
showing 2 items of 2 documents
Establishment of a commercial organic hopyard in a Mediterranean environment: Production attributes and their relationship with soil texture
2023
The cultivated hops are recently moving towards new growing areas in Southern Europe, boosted by the increasing number of craft breweries and by the higher vulnerability to climate change observed, for this crop, in the traditional growing regions. Despite this clear market and geographic trend, there is a lack of knowledge about pedoclimatic needs and agronomic performances of hops grown in the Mediterranean environment. Particularly, the agronomic potential of a new hopyard during its establishment period is poorly studied even in traditional growing zones. Moreover, a restricted number of plants were usually sampled to gather the few data available, thus leading to a probable overestimat…
Immunomodulatory activity of Humulus lupulus bitter acids fraction: Enhancement of natural killer cells function by NKp44 activating receptor stimula…
2019
Abstract Humulus lupulus (Hop) contains numerous metabolites with anticancer potential. Despite this, their immunomodulatory activity, and in particular of bitter acids, is unknown. In this study, we demonstrated that a Hop pellet extract fraction containing bitter acids possesses immunomodulatory activity by enhancing Natural Killer (NK) cells function. After fractionation by semi-preparative Liquid Chromatography, three different fractions were obtained. The phytocomplex and the fractions were tested to verify the ability to modulate the NK compartment. Cytofluorimetric analysis revealed that a fraction containing bitter acids was able to up-regulate of NKG2D and NKp44 activating receptor…